Best Nootropics Natural and Synthetic

Nootropics are supplements that have the ability to improve short-term memory, long-term memory, focus, critical thinking and many other cognitive functions.

There is little clinical data that demonstrates the efficiency of nootropics, so we rely on the experiences of many long-term users of the compound to obtain information about its effects.

In this article, I will discuss the two categories of nootropics: natural nootropics and synthetic nootropics.

Best Natural nootropics

Natural nootropics are great cognitive enhancing supplements, but due to the absence of universal clinical trials, the side effects of these nootropics are unknown. On the other hand, natural compounds tend to pose a lower risk of harmful effects.

Here is a list of the best natural nootropics and their benefits:


Huperzine-A is used as a potential treatment for Alzheimer’s. It is still considered a natural nootropic, even though the compound is prepared in a laboratory.

Huperzine-A is also a neural antioxidant. It appears in your bloodstream fifteen minutes after you ingest it. The most notable biochemical function of this nootropic is that it allows other neuro-active compounds to have a deeper effect.


5-HTP contains a compound similar to serotonin (which is one of the most important neurotransmitters in our brain). The compound can increase feelings of happiness. Not bad, right? However, you should be careful when using this compound. You shouldn’t mix it with other medications.

When taken properly, the supplement has positive health benefits. These benefits include weight loss, suppressing night terrors, etc.

If anything, 5-HTP is a proven mood-stabilizer.

GABA (Gamma-Amino-Butyric Acid)

Gaba is the best supplement for reducing anxiety. Apart from that, GABA also serves as a supplement for boosting growth hormone levels. However, this nootropic requires a higher dosage than the other supplements on this list. Also, some patients are unresponsive to the effects of GABA.

Other natural nootropics

Other natural nootropics to consider are Choline, Alpha GPC, L-Theanine, PEA, Lion’s Mane, Bacopa, Ginko Biloba, Rennet, Rhodiola, and NALT.

Best Synthetic nootropics

Most people associate the term “synthetic” with “unhealthy”. That isn’t necessarily the case. Synthetic nootropics do have a more intense effect than natural nootropics. Bare that in mind before consuming any of the supplements on this list.


Aniracetam is both popular and effective due to the fact that it’s fat-soluble. The main benefits of this supplement are its mental enhancement abilities. These include increased memory capacity, focus, etc.


Oxiracetam stimulates NDMA receptors, as well as AMPA receptors. It’s one of the best synthetic nootropics on the list. Also, it’s water-soluble which makes it great for powdered consumption.

However, this compound is quite hard to come by in stores.


Phenibut is best for reducing stress and anxiety. But the best thing about this nootropic is that it doesn’t cause drowsiness. So, you’ll feel more relaxed, yet fully alert.

However, Phenibut isn’t FDA approved in the USA. You can’t use it to treat diseases or medical conditions. Although, you can still buy it as a dietary supplement.


Noopept is another patented synthetic compound that isn’t FDA approved. That’s why it is (like Phenibut) sold as a dietary supplement. Among other things, Noopept provides a psychostimulatory effect. This supplement is a great way to reduce stress levels without using pharmaceuticals.


Vinpocetine is a semi-synthetic nootropic. That doesn’t mean it’s any less potent than the rest of the supplements on the list. The compound is clinically proven to treat cerebrovascular diseases, as well as memory-related diseases such as Alzheimer’s.

However, you should take Vinpocetine with other nootropics for better effect.

How to choose the best nootropic

It’s quite difficult to pick a specific nootropic brand from the list. Perhaps the best way to determine what nootropic suits your needs is to try out the natural ones first. If they have a satisfying effect, then you can continue using natural compounds.

However, if you’re not satisfied with the effects, you should move on to the synthetic supplements, as they are stronger.

In any case, whatever your choice, nootropics are safe for use.